Dr. Mathieu Di Miceli

Mathieu photo

Lecturer in Biomedical Science

School of Science and the Environment

Biological Sciences

Contact Details

email: m.di-miceli@worc.ac.uk

Dr Mathieu Di Miceli is a lecturer within the School of Science and the Environment.

Mathieu joined the 桔子短视频 in 2021 after his long background in neuroscience. Mathieu has developed his skills in electrophysiology in Dr Gronier’s (De Montfort University) and Dr Layé’s (Université de Bordeaux) laboratories, studying the neurophysiological mechanisms following psychostimulant exposure, as well as the link between dietary lipid intake and synaptic plasticity. He is currently investigating the pathological alterations that can lead to neurophysiological dysfunctions in the brain, using in silico modelling of neural circuits.

Teaching & Research

Teaching

BIOL1004 Human Anatomy and Physiology – Lecturer
BIOL1003 Health and Disease – Lecturer
BIOS2106 Systems Physiology I – Lecturer
BIOS3106 Pharmacology – Lecturer
BIOS3108 Systems Physiology II – Lecturer
BIOS2104 Human Genetics – Module Leader

Research

Mathieu started his career in neurophysiology in 2012, In the team of Dr Mireille Natoli-Lerner. The focus was on epileptiform activity in an in vitro model of epilepsy, using patch-clamp field electrophysiology. This research aimed at understanding how dysfunctions the blood brain barrier could lead to epilepsy.

Mathieu pursued his career studying myocardial infraction in acutely dissociated cardiac myocytes from rats, in the team of Dr Alain Lacampagne. This project aimed at understanding if the antioxidant molecule N Acetyl Cystein could improve the excitability and/or the contractibility of cardiomyocytes, using field  electrophysiology. 

In 2012, Mathieu joined De Montford University, in Dr Gronier’s team, where his PhD project focused on the possible long-term consequences of psychostimulant intake. More precisely, the study was about the relationship between methylphenidate exposure and neurochemical alterations in brain regions controlling motivation and cognition, using in vivo single-cell extracellular electrophysiology. 

Mathieu's post-doctoral studies, in Dr Sophie Layé’s team, focused on the relationship between dietary polyunsaturated fatty acids, endocannabinoid receptors and synaptic plasticity, using ex vivo patch clamp electrophysiology. 

Mathieu's research interests include basal ganglia neurophysiology, neuronal circuitry and in silico modelling. Besides, Mathieu is also fascinated about big data analysis, using bioinformatics. 

Mathieu also has keen interests in astrophysics and generative art. 

Qualifications

Doctorate (2016) De Montfort University, Leicester, England.
Master’s degree (2012) Université Montpellier, Montpellier, France.
Bachelor’s degree (2010). Université Montpellier, Montpellier, France.

Doctorate (2016)  De Montfort University, Leicester, England.
Master’s degree (2012). Université Montpellier, Montpellier, France.

Qualification aux fonctions de Maître de Conférences (2019). Université de Bordeaux, Bordeaux, France

UK Home Office. Animals (Scientific Procedures) Act 1986 (2012). University of Nottingham, England.

First Aid Certificate (2005). Fire department of Saint-Martin-De-Londres, France.

Publications

  1. Martin, H., Bullich, S., Martinat, M., Chataigner, M., Di Miceli, M., Simon, V., Clark, S., Butler, J., Schell, M., Chopra, S., Chaouloff, F., Kleinridders, A., Cota, D., De Deurwaerdere, P., Pénicaud, L., Layé, S., Guiard, B.P. and Fioramonti, X. Insulin modulates emotional behavior through a serotonin-dependent mechanism. Molecular Psychiatry, 2022, doi:10.1038/s41380-022-01812-3.

  2. Di Miceli, M.; Derf, A.; Gronier, B. Consequences of Acute or Chronic Methylphenidate Exposure Using Ex Vivo Neurochemistry and In Vivo Electrophysiology in the Prefrontal Cortex and Striatum of Rats. Int. J. Mol. Sci. 2022, 23, 8588, doi:10.3390/ijms23158588.

  3. Di Miceli, M.; Martinat, M.; Rossitto, M.; Aubert, A.; Alashmali, S.; Bosch-Bouju, C.; Fioramonti, X.; Joffre, C.; Bazinet, R.P.; Layé, S. Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice. Int. J. Mol. Sci. 2022, 23, 6650, doi:10.3390/ijms23126650.

  4. Di Miceli, M.; Omoloye, A.; Gronier, B. Characterisation of Methylphenidate-Induced Excitation in Midbrain Dopamine Neurons, an Electrophysiological Study in the Rat Brain. Prog. Neuropsychopharmacol. Biol. Psychiatry 2021, 112, 110406, doi:10.1016/j.pnpbp.2021.110406.

  5. Martinat, M.; Rossitto, M.; Di Miceli, M.; Layé, S. Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders. Nutrients 2021, 13, doi:10.3390/nu13041185.

  6. Chataigner, M.; Lucas, C.; Di Miceli, M.; Pallet, V.; Laye, S.; Mehaignerie, A.; Bouvret, E.; Dinel, A.-L.; Joffre, C. Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging. Front. Nutr. 2021, 8, 750292, doi:10.3389/fnut.2021.750292.

  7. Lin, L.; Metherel, A.H.; Di Miceli, M.; Liu, Z.; Sahin, C.; Fioramonti, X.; Cummins, C.L.; Layé, S.; Bazinet, R.P. Tetracosahexaenoylethanolamide, a Novel n-Acylethanolamide, Is Elevated in Ischemia and Increases Neuronal Output. J. Lipid Res. 2020, doi:10.1194/jlr.RA120001024.

  8. Di Miceli, M.; Husson, Z.; Ruel, P.; Layé, S.; Cota, D.; Fioramonti, X.; Bosch-Bouju, C.; Gronier, B. In Silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties. Front. Neural Circuits 2020, 14, doi:10.3389/fncir.2020.00051.

  9. Di Miceli, M.; Bosch-Bouju, C.; Layé, S. PUFA and Their Derivatives in Neurotransmission and Synapses: A New Hallmark of Synaptopathies. Proc. Nutr. Soc. 2020, 1–16, doi:10.1017/S0029665120000129.

  10. Berland, C.; Montalban, E.; Perrin, E.; Di Miceli, M.; Nakamura, Y.; Martinat, M.; Sullivan, M.; Davis, X.S.; Shenasa, M.A.; Martin, C.; et al. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metab.2020, 31, 773-790.e11, doi:10.1016/j.cmet.2020.02.010.

  11. Di Miceli, M.; Omoloye, A.; Gronier, B. Chronic Methylphenidate Treatment during Adolescence Has Long-Term Effects on Monoaminergic Function. J. Psychopharmacol. Oxf. Engl. 2019, 33, 109–121, doi:10.1177/0269881118805494.

  12. Di Miceli, M.; Gronier, B. Pharmacology, Systematic Review and Recent Clinical Trials of Metadoxine. Rev. Recent Clin. Trials 2018, doi:10.2174/1574887113666180227100217.

  13. Gronier, B.; Savignac, H.M.; Di Miceli, M.; Idriss, S.M.; Tzortzis, G.; Anthony, D.; Burnet, P.W.J. Increased Cortical Neuronal Responses to NMDA and Improved Attentional Set-Shifting Performance in Rats Following Prebiotic (B-GOS®) Ingestion. Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol. 2018, 28, 211–224, doi:10.1016/j.euroneuro.2017.11.001.

  14. Di Miceli, M.; Gronier, B. Psychostimulants and Atomoxetine Alter the Electrophysiological Activity of Prefrontal Cortex Neurons, Interaction with Catecholamine and Glutamate NMDA Receptors. Psychopharmacology (Berl.) 2015, 232, 2191–2205, doi:10.1007/s00213-014-3849-y.

  15. Michalak, Z.; Lebrun, A.; Di Miceli, M.; Rousset, M.-C.; Crespel, A.; Coubes, P.; Henshall, D.C.; Lerner-Natoli, M.; Rigau, V. IgG Leakage May Contribute to Neuronal Dysfunction in Drug-Refractory Epilepsies with Blood-Brain Barrier Disruption. J. Neuropathol. Exp. Neurol.2012, 71, 826–838, doi:10.1097/NEN.0b013e31826809a6.